Real oxidative chemistry with a narrow local-wound signal, but inherently injurious and with poor systemic evidence — under study, with a strong caution. Not authorized for any medical use by the FDA.
Origin & lineage
Alternative / integrative practice; EBOO = extracorporeal blood ozonation.
Claimed mechanism
Oxidative disinfection and inflammation modulation; EBOO ozonates blood extracorporeally.
Plausibility
Weak — real chemistry, inherently injurious; systemic benefit unestablished.
Evidence — grade C/D
Narrow local signal; no systemic evidence; high risk of bias.
Flag
caution — inherently injurious chemistry; narrow local use only
Market
Makers: Clinic ozone-generator makers; EBOO setups. Models: Medical ozone generators; EBOO rigs. Price: Generators $1–10K; EBOO setups tens of thousands.
Kernel — keep vs set aside
Keep — real substrate
Localized wound-ozone research exists (real chemistry).
Set aside — claim
Systemic claims are unestablished; EBOO weaker still; the chemistry is inherently injurious — narrow local use only.
Regulatory status by jurisdiction
Registration or clearance is a market-access fact, never proof of efficacy.
US — FDA
NOT authorized for any medical use; FTC COVID actions; Import Alert 89-08.